TOFMOD Workshop 2020 (satellite event of Virtual Physiological Human conference 2020)

Title: Experiments for validation of biomechanical models: blood-like experimental fluids

Speaker: Radek Galabov, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Abstract: A lattice Boltzmann method was implemented to model blood flow in large arteries [1] and a suitable flow phantom was needed to validate the advanced non-Newtonian model [2] in vitro. One question regarding the in vitro experiment accuracy was the medium used. In this work four media are considered, namely pure water, glycerine solution, glycerine+xanthan gum solution and sucrose+xanthan gum solution, to simulate the non-Newtonian property of blood. The media were tested and compared in an MRI experiment and their viscosity, dependent on shear rate, was measured using rotational viscometer. For high shear rates occuring in large arteries glycerine solution proved to be sufficient as an experimental medium. With lower shear rates, sucrose+xantham gum solution is suggested to produce the best results.

References
[1] Radek Fucik, Radek Galabov, Petr Paus, Pavel Eichler, Jakub Klinkovsky, Robert Straka, Jaroslav Tintera, Radomir Chabiniok: Investigation of phase-contrast magnetic resonance imaging underestimation of turbulent flow through the aortic valve phantom: experimental and computational study using lattice Boltzmann method. MAGMA. 2020 Feb 27. doi: 10.1007/s10334-020-00837-5

[2] Katerina Skardova, Pavel Eichler, Radek Fucik, Tomas Oberhuber, Radomir Chabiniok: Investigation of non-Newtonian effects in pathological vessel stenoses using lattice Boltzmann method, VPH 2020 Modeling-vascular poster I session (Wed. August 26, 11AM-12PM).