TOFMOD Workshop 2020 (satellite event of Virtual Physiological Human conference 2020)

Speaker: Maria Gusseva, Inria Saclay, France

Title: Prediction of pulmonary valve replacement based on RV mechanics

Sustained exposure to right ventricular (RV) volume and pressure overload may lead to irreversible myocardial remodeling or even to a sudden death from cardiac arrest or arrhythmias. The present work aims to combine clinical data of cardiovascular magnetic resonance (CMR) and pressure catheter in a cohort of repaired tetralogy of Fallot patients with a biomechanical heart model in order to predict patients' response to pulmonary valve replacement therapy (PVR). We are evaluating the capabilities of the model to predict immediate post-PVR changes in RV end-diastolic volume, pulmonary artery flow and RV mechanical properties (such as ventricular contractility). The capabilities to predict the post-PVR changes extend the application of data-modeling framework beyond the assessment of current RV functionality [1].


[1] M. Gusseva, A. Tandon, P. Moireau, K. Hasbani, G. Greil, T. Hussain, D. Chapelle, R. Chabiniok: Biomechanical modeling to assess the functionality of right heart myocardium: Application to tetralogy of Fallot, VPH 2020, Clinical: cardiac session poster (Wed August 26, 12-1PM).