TOFMOD Workshop 2020 (satellite event of Virtual Physiological Human conference 2020) Speaker: Alistair Young, School of Biomedical Engineering & Imaging Sciences, St Thomas' Hospital, King's College London, UK Title: Biventricular statistical modeling for Tetralogy of Fallot Abstract: Features of right ventricular (RV) remodeling in patients with repaired tetralogy of Fallot (rTOF) include RV dilation and apical bulging, which are associated with pulmonary regurgitant volume (PRV). However, relationships between right and left ventricular shape in rTOF are less well understood. We show how a biventricular shape model can be customized to CMR images and morphometric scores computed using linear regression to quantify shape variations associated with PRV, age, sex, height, and weight. Preliminary results indicate that Increasing PRV is associated with RV dilation particularly in the outflow tract and apex, in conjunction with decreased septal-lateral dimension (flattening) of the LV as well as a systolic septal motion towards the RV. This method shows promise to help understand the remodelling patterns undergone in rTOF patients.